# GATE Syllabus 2018 for Biotechnology- Check complete Details

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To clear the GATE Biotechnology Paper, aspirants should have the complete details of Syllabus. Check the GATE Syllabus for Biotechnology Here

GATE Syllabus 2018 for Biotechnology- IIT Guwahati is all set to hold Graduate Aptitude Test in engineering on February 03, 04, 10 & 11, 2018. Aspirants should have the complete details of GATE Biotechnology Syllabus in order to crack the examination. The syllabus of GATE Biotechnology 2018 lists all those topics that students need to study in order to attempt the question paper in Biotech. General Aptitude is a compulsory section in all GATE papers.

GATE 2018 (Graduate Aptitude Test in Engineering) is an all India examination administered and conducted jointly by the Indian Institute of Science (IISc) and seven Indian Institutes of Technology (IITs) on behalf of the National Coordination Board - GATE, Department of Higher Education, Ministry of Human Resource Development (MHRD), Government of India, for admission to Post Graduation/PhD courses in Engineering and Architecture.

## GATE Biotechnology Syllabus 2018

### Part I-

There will be 65 questions carrying 100 marks, out of which 10 questions will be carting 15 marks are in General Aptitude (GA). Questions in GA will be based in A) Verbal Ability and B) Numerical Ability.

### Part II-

Section 1: Engineering Mathematics

• Linear Algebra: Matrices and determinants, Systems of linear equations, Eigen values and Eigen vectors.
• Calculus: Limit, Partial derivatives, continuity and differentiability, Maxima and minima, Test for convergence, Sequences and series, Fourier Series.
• Differential Equations: Linear and nonlinear first order ODEs, higher order ODEs with constant coefficients, Cauchy’s and Euler’s equations, Laplace transforms, PDE-Laplace, heat and wave equations. Probability and
• Statistics: Mean, median, mode and standard deviation, Poisson, Random variables, Correlation and regression analysis, normal and binomial distributions.
• Numerical Methods: Solution of linear and nonlinear algebraic equations, Single and multistep methods for differential equations, Integration of trapezoidal and Simpson’s rule.

Section 2: General Biotechnology

• Biochemistry: Biomolecules-structure and functions; Biological membranes, structure, action potential and transport processes; Enzymes- classification, Basic concepts and designs of metabolism photosynthesis, kinetics and mechanism of action; respiration and electron transport chain; Bioenergetics
• Microbiology: Viruses- structure and classification; Microbial classification and diversity(bacterial, algal and fungal); Microbial growth and nutrition; Methods in microbiology; Aerobic and anaerobic respiration; Nitrogen fixation; Microbial diseases and host-pathogen interaction
• Cell Biology: Prokaryotic and eukaryotic cell structure; Cell-Cell communication, Cell cycle and cell growth control; Cell signaling and signal transduction
• Molecular Biology and Genetics: Molecular structure of genes and chromosomes; Nucleic acid replication, transcription, translation and their regulatory mechanisms in prokaryotes and eukaryotes; Mendelian inheritance; Complementation; Mutations and mutagenesis; Linkage, recombination and chromosome mapping; Gene interaction; Extra chromosomal inheritance; Microbial genetics (plasmids, transformation, transduction, conjugation); RNA interference; DNA damage and repair; Horizontal gene transfer and Transposable elements; Chromosomal variation; Molecular basis of genetic diseases
• Analytical Techniques: Principles of microscopy-light, electron, fluorescent and confocal; Principles of spectroscopy-UV, visible, CD, IR, FTIR, Raman, MS,NMR; Centrifugation- high speed and ultra; Principles of chromatography- ion exchange, gel filtration, hydrophobic interaction, affinity, GC,HPLC, FPLC; Electrophoresis; Microarray
• Immunology: History of Immunology; Innate, humoral and cell mediated immunity; Antigen; Antibody structure and function; Molecular basis of antibody diversity; Synthesis of antibody and secretion; Antigen-antibody reaction; Antigen processing and presentation; Complement; Primary and secondary lymphoid organ; B and T cells and macrophages; Polyclonal and monoclonal antibody; Major histocompatibility complex (MHC); Regulation of immune response; Hypersensitivity; Immune tolerance; Autoimmunity; Graft versus host reaction.
• Bioinformatics: Major bioinformatic resources and search tools; Sequence analysis (biomolecular sequence file formats, scoring matrices, sequence alignment, phylogeny); Sequence and structure databases; Data mining and analytical tools for genomic and  proteomic studies, ; Molecular dynamics and simulations.

Section 3: Recombinant DNA Technology

Restriction and modification enzymes; Vectors; plasmid, bacteriophage and other viral vectors, ; mammalian and plant expression vectors; cosmids, Ti plasmid, yeast artificial chromosomecDNA and genomic DNA library; Transposons and gene targeting; Gene isolation, cloning and expression; DNA labeling; DNA sequencing; Polymerase chain reactions; DNA fingerprinting; Southern and northern blotting; In-situ hybridization; RAPD, RFLP; Site-directed mutagenesis; Gene transfer technologies; Gene therapy

Section 4: Plant and Animal Biotechnology

Totipotency; Regeneration of plants; Tissue culture and Cell suspension culture system: methodology, kinetics of growth and, nutrient optimization; Plant growth regulators and elicitors; Production of secondary metabolites by plant suspension cultures; transgenic plants; Hairy root culture; Plant products of industrial importance Animal cell culture; Animal cell and tissue preservation; Anchorage and non-anchorage dependent cell culture; Kinetics of cell growth; media composition and growth conditions; Micro & macro-carrier culture; Hybridoma technology; Stem cell technology; Animal cloning; Transgenic animals

Section 5: Bioprocess Engineering and Process Biotechnology

• Chemical engineering principles, Principle of reactor design, ideal and non-ideal multiphase bioreactors, mass and heat transfer; Rheology of fermentation fluids, Media formulation and optimization; Kinetics of microbial growth, substrate utilization and product formation; Aeration and agitation; Instrumentation control and optimization; Sterilization of air and media; Batch, fed-batch and continuous processes; Various types of microbial and enzyme reactors; Unit operations in solid-liquid separation and liquid-liquid extraction; Process scale-up, economics and feasibility analysis
• Engineering principle of bioprocessing- Upstream production and downstream; Bioprocess design and development from lab to industrial scale; Microbial, animal and plant cell culture platforms; Production of biomass and primary/secondary metabolites; Biofuels, Bioplastics, industrial enzymes, antibiotics; Large scale production and purification of recombinant proteins; Industrial application of chromatographic and membrane based bioseparation methods; Immobilization of biocatalysts (enzymes and cells) for bioconversion processes; Bioremediation-Aerobic and anaerobic processes for stabilization of solid / liquid wastes

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